GHRP-2 / GHRP-6

How do GHRP-2 and GHRP-6 work?

GHRP-2 and GHRP-6 are synthetic, non-natural peptides that stimulate growth-hormone secretion and share no structural homology with GHRH [1]. GHRP-6 was the first hexapeptide extensively studied in humans, and prolonged GHRP use raises IGF-1 levels in both animals and humans [1]. They belong to the broader class of growth hormone secretagogues.

What safety signals has FDA flagged?

FDA's active Category 2 listing, in effect since September 29, 2023, cites risk of immunogenicity from aggregation and peptide-related impurities for both peptides [2]. For GHRP-2, FDA notes reports of serious adverse events, including increased insulin requirement, death of critically ill study subjects, infection and pancreatitis, though causality has not been established [2]. For GHRP-6, FDA cites potential effects on cortisol and increased blood glucose from decreased insulin sensitivity [2].

Are GHRP-2 and GHRP-6 FDA-approved or prohibited in sport?

Neither is FDA-approved. FDA's list current as of May 14, 2026 places both in Category 3, bulk substances nominated without adequate supporting evidence [3]. Both also appear by name among the growth hormone-releasing peptides the World Anti-Doping Agency's 2026 list prohibits at all times, in and out of competition [4].