Comorbidity
Also called: weight-related comorbidities
Clinical reviewer: Jacob Moore, MD · Last checked September 24, 2026
What is a comorbidity?
Comorbidity is the condition of having two or more diseases at the same time. On GLP-1 drug labels, the phrase weight-related comorbid condition sets eligibility: Wegovy and Zepbound are indicated for adults with obesity, or with overweight plus at least one such condition, such as high blood pressure.
What does weight-related comorbid condition mean on GLP-1 labels?
Comorbidity is the condition of having two or more diseases at the same time [1]. Wegovy trials enrolled adults with obesity, or with overweight and at least one weight-related comorbid condition, such as treated or untreated dyslipidemia or hypertension [2]. Zepbound was approved for adults with overweight (a BMI of 27 kg/m2 or greater) and at least one weight-related condition such as high blood pressure, type 2 diabetes, or high cholesterol [3].
What health problems count as weight-related comorbidities?
NIDDK lists health risks linked to overweight and obesity, including type 2 diabetes, high blood pressure, heart disease, stroke, metabolic syndrome, fatty liver diseases, some cancers, breathing problems such as sleep apnea, osteoarthritis, and kidney disease [4]. Nearly 9 in 10 people with type 2 diabetes have overweight or obesity [4].
Frequently asked questions
What examples of weight-related comorbid conditions appear on GLP-1 labels?+−
Wegovy trial eligibility criteria mention treated or untreated dyslipidemia or hypertension, and Zepbound's approval names high blood pressure, type 2 diabetes, or high cholesterol as examples.
Does a comorbidity have to be caused by weight?+−
Not in general. Comorbidity simply means having two or more diseases at the same time; GLP-1 labels narrow it to weight-related conditions for eligibility.
Related terms
Sources
This entry is for education and is not medical advice. Talk with a licensed clinician about your own situation before starting, stopping, or changing any treatment.
